Nashy
Immortal
Senior Staff
- Mar 5, 2008
- 54,377
- 34,658
But you don't read the news, so how would you know?
There's a good reason I rarely read the news [icon_winkNashy said:But you don't read the news, so how would you know?
Foordy said:The Dragons breached the quarantine with Boyd's presence in the away dressing rooms before last nights match with the Titans
http://www.leaguehq.com.au/news/lhqnews ... 19254.html
Good question eusa_thinkJe$ter said:How the frick do AFL teams get allowed to travel in and out of Victoria all the time and not have any reported implications from Swine Flu, yet rugby league does?
The swine flu virus is rapidly making its way around the world, but it has been relatively mild so far, causing only 139 confirmed deaths. Could it mutate into something more lethal?
Scientists looking at its genetic structure say there is no obvious pressure for it to do so — no reason for this virus to “want,†in the Darwinian sense, to kill more of its hosts.
It is already doing a near-perfect job of keeping itself alive by invading human noses and inducing humans to cough it from one to another, said Dr. W. Ian Lipkin, director of the Center for Infection and Immunology at Columbia University’s Mailman School of Public Health.
“A really aggressive flu that quickly kills its host†— like SARS and H5N1 avian flu — “gives itself a problem,†Dr. Lipkin said.
The current swine flu strain lacks several genes believed to increase lethality, including those that code for two proteins known as PB1-F2 and NS-1, and one that codes for a tongue-twister called the polybasic hemagglutinin cleavage site.
PB1-F2 appears to weaken the protective membrane of the energy-producing mitochondria in an infected cell, ultimately killing the cell. Specifically, it attacks dendritic cells, the sentinels of the immune system. Its lethality could be accidental — a protein good at killing sentries might just go on killing other cells once inside the fort.
All pandemic flus, including those of the Spanish, Hong Kong and Asian flus, make PB1-F2. So does the H5N1 bird flu. The current swine strain does not.
The NS-1 protein also maims the immune response by blocking interferon, an antiviral protein made by cells.
Very lethal bird flus also have the unusual cleavage site, which allows the hemagglutinin spike on the virus’s shell to split and inject its genetic instructions into different kinds of cells, like those in the lungs and the gut.
Such an addition to the novel H1N1 would be very dangerous. But because it has been found only in avian flus, it is unlikely to become a component of a human flu, Dr. Palese said. Even the 1918 virus, which was avian in origin, lacked it.
A much more likely change, scientists have said, is that the H1N1 swine flu will become resistant to the antiviral drug Tamiflu. A gene for Tamiflu resistance is now almost universal in seasonal H1N1 flus.
If that happens, the world’s Tamiflu stockpiles will be all but worthless, and doctors may have to switch to Relenza, which is a powder used with an inhaler, which makes it more expensive and harder to take.